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KMID : 0384119930130030357
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Korean Journal of Clinical Pathology
1993 Volume.13 No. 3 p.357 ~ p.362
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A Review of Six Cases of Acute Megakaryoblastic Leukemia
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Abstract
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Acute megakaryoblastic leukemia(AML.M7) is a rare type of leukemia, characterized by proliferation of megakaryocytic elements in the bone marrow with increased reticulin fibers. It has been recently added to FAB classification in 1985 and can be
usually
diagnosed by ultrastructural cytochemistry or immunological marker studies. We have experienced six cases of M7 from 1985 to 1993, and analyzed their characteristics. A case of transient myeloproliferative disorder, initially diagnosed as M7 was
excluded in this study. The age range was from 38 days to 4 years, and male to female ratio was 1:2. All cases showed severe hepatosplenomegaly. Two cases were combined with Down syndrome, and two cases were congenital leukemia. Peripheral blood
findings showed variable range of hemoglobin, WBC and platelet counts. Blasts were present in all cases, comprising 2 to 34% of the peripheral blood cells. Bone marrow biopsy showed packed marrow pattern in 5 cases and variable degree of
reticulin
fibrosis in all cases. On cytochemical studies, peroxidase stain was all negative, but α-naphthyl acetate esterase(ANAE) and PAS were all positive with a variable pattern. Platelet specific monoclonal antibody study was performed in five cases,
of
which all were positive. In conclusion, if leukemic cells having atypical cytoplasmic budding are noted in the peripheral blood, the platelet specific monoclonal antibody studies are needed to rule out M7.
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KEYWORD
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